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判断题

新闻是事实的报道，事实是第一性的，新闻是第二性的，客观事实在先，新闻报道在后。   

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多项选择题

Phenytoin sodium requires therapeutic drug monitoring for the following reasons: ( )
A、It has nonlinear pharmacokinetic characteristics
B、Its toxic reactions and seizures are easily distinguished
C、The effective drug concentration range the safety range is wide
D、The internal processes of drugs vary greatly from individual to individual